神经发生
海马结构
莫里斯水上航行任务
海马体
神经科学
心理学
水迷宫
生物
作者
Joana Gil-Mohapel,Patrícia S. Brocardo,Will Choquette,Russ Gothard,Jessica M. Simpson,Brian R. Christie
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2013-09-23
卷期号:8 (9): e75125-e75125
被引量:101
标识
DOI:10.1371/journal.pone.0075125
摘要
The hippocampus plays a crucial role in the formation of spatial memories, and it is thought that adult hippocampal neurogenesis may participate in this form of learning. To better elucidate the relationship between neurogenesis and spatial learning, we examined both across the entire life span of mice. We found that cell proliferation, neuronal differentiation, and neurogenesis significantly decrease with age, and that there is an abrupt reduction in these processes early on, between 1.5-3 months of age. After this, the neurogenic capacity continues to decline steadily. The initial abrupt decline in adult neurogenesis was paralleled by a significant reduction in Morris Water Maze performance, however overall learning and memory remained constant thereafter. Further analysis of the search strategies employed revealed that reductions in neurogenesis in the aging brain were strongly correlated with the adoption of spatially imprecise search strategies. Overall, performance measures of learning and memory in the Morris Water Maze were maintained at relatively constant levels in aging animals due to an increase in the use of spatially imprecise search strategies.
科研通智能强力驱动
Strongly Powered by AbleSci AI