羧苄青霉素
头孢西丁
脆弱类杆菌
替卡西林
微生物学
头孢唑林
克林霉素
头孢菌素
青霉素
化学
抗生素
克拉维酸
生物
细菌
阿莫西林
氨苄西林
金黄色葡萄球菌
遗传学
作者
Richard E. Bryant,Abdel L. Rashad,Joyce A. Mazza,Dianne Hammond
标识
DOI:10.1093/infdis/142.4.594
摘要
Pus was obtained from patients with polymicrobial intraabdominal abscesses or polymicrobial empyema. Physical and chemical characteristics of 12 specimens were examined, and bacterial isolates were enumerated. Pus supernatant of six specimens rapidly inactivated penicillin, cephalothin, and cefazolin. Carbenicillin and ticarcillin were similarly degraded by supernatant of certain pus specimens. Cefoxitin, chloramphenicol, and clindamycin were not appreciably inactivated by pus supernatant. Degradation of penicillin and cephalosporin congeners in pus was due to the presence of beta-lactamase, as shown by chemical interaction with nitrocefin, chromatography, and inhibition by the beta-lactamase inhibitor clavulanic acid. Pus supernatant containing beta-lactamase activity reduced the bactericidal activity of carbenicillin against Bacteroides fragilis in whole pus in an abscess model in vitro. Bactericidal activity of clindamycin or cefoxitin was not impaired in pus containing beta-lactamase.
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