DNA甲基化
甲基转移酶
表观遗传学
体育锻炼的表观遗传学
生物
甲基化
RNA导向的DNA甲基化
DNA
CpG站点
染色质
DNMT1型
DNA甲基转移酶
遗传学
分子生物学
基因
基因表达
作者
Albert Jeltsch,Renata Z. Jurkowska
标识
DOI:10.1016/j.tibs.2014.05.002
摘要
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early development, and methylation at hemimethylated CpG sites is specifically maintained by the Dnmt1 maintenance methyltransferase. However, substantial experimental evidence from the past decade indicates that this simple model needs to be revised. DNA methylation can be described by a dynamic stochastic model, in which DNA methylation at each site is determined by the local activity of DNA methyltransferases (Dnmts), DNA demethylases, and the DNA replication rate. Through the targeting and regulation of these enzymes, DNA methylation is controlled by the network of chromatin marks.
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