A Stereoselective Total Synthesis of Decarestrictine I

Abstract A convergent and stereoselective total synthesis of decarestrictine I, a polyketide natural product, is described. Both acid and alcohol fragments were prepared from the readily available L ‐malic acid via StillGennari olefination and Sharpless asymmetric epoxidation. The Steglich esterification and ring‐closing metathesis (RCM) are employed to combine both acid and alcohol fragments.