原肌球蛋白受体激酶B
神经科学
消光(光学矿物学)
扁桃形结构
神经营养因子
原肌球蛋白受体激酶A
神经营养素
脑源性神经营养因子
心理学
受体
生物
遗传学
古生物学
作者
Jasmeer P. Chhatwal,Lisa Stanek-Rattiner,Michael Davis,Kerry J. Ressler
摘要
Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.
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