细胞外基质
生物相容性材料
材料科学
生物医学工程
生物粘附
细胞外
负压伤口治疗
压力传感器
压力敏感
伤口愈合
医学
导电体
导电的
纳米技术
刺激
电极
临床实习
基质(化学分析)
三维打印
支架
动物模型
结构完整性
压力(语言学)
电阻和电导
高压
作者
Rui Tang,Ya-Jun Fu,Chenchen Liu,Jiang-nan ZHAO,Kang Yang,Qiyan Fu,Si-Yu Long,Jingsheng Yuan,Xing Zhao,Peng Yu,Junliang Wu,Bo Yin,Ming-Bo Yang,Wei Yang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2025-11-18
标识
DOI:10.1021/acsnano.5c16624
摘要
Pressure ulcers are substantial contributors to mortality in immobilized or bedbound patient populations, characterized by elevated morbidity rates, multifaceted therapeutic challenges, and high recurrence rates. Nevertheless, existing clinical paradigms for pressure ulcers lack a systematic approach to pathology management, encompassing wound repair, pressure redistribution, and biophysical monitoring. This study underscores an extracellular matrix (ECM) guided design for real-time monitoring and timely interventions in pressure ulcers. A conductive hydrogel network is first intertwined with an elastic sponge, referencing the ECM architecture, to form a moisturizing and bioadhesive dressing. The conductive dressing is assembled with commercial band-aid and gauze into laminated patches. The hierarchical assembly offers a broad stress response range and low hysteresis, resulting in exceptional sensitivity and linearity in self-powered pressure sensing. The patch is endowed with commendable breathability and good antimicrobial properties, which synergistically enhance the therapeutic outcomes. Moreover, the biocompatible patches can not only activate calcium ion channels and guide cell proliferation via a stable, continuous electrical stimulation pathway, but also provide alerts for pressure ulcers by detecting electrical signals from multiple predilection sites. This study represents a full-cycle management strategy for pressure ulcers, encompassing the collection of physiological data and the repair of tissue damage.
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