Enantioselective construction of chiral quinoline scaffold via a Michael addition/ O -alkylation sequence

-alkylation cascade between hydroxyquinolines and chloronitroalkenes was developed, constructing chiral dihydrofuroquinoline scaffolds in high enantioselectivity under mild conditions. The direct modification of hydroxylcamptothecin and the discovery of anti-tumour (MCF-7 cell lines) leads highlight the potential of this process.