Functional characterisation of the mouse lymphotoxin-b receptor (LTb R) promoter.

INTRODUCTION The LTbetaR, a member of the tumor necrosis factor (TNF) family, is functionally activated upon binding of the membrane-bound, heterotrimer, lymphotoxin alpha1beta2 (LTalpha1beta2) molecule [1-3]. Interestingly, LTbetaR is expressed on a wide range of cell types with the exception of lymphocytes, whereas the expression of the ligand is restricted to activated lymphocytes [4]. Currently the biological functions of this [...]