抗菌活性
蜡样芽孢杆菌
发酵
细菌
二苯醚
金黄色葡萄球菌
蜡样体
大肠杆菌
微生物学
化学
生物
分离(微生物学)
真菌学
食品科学
植物
生物化学
有机化学
遗传学
基因
作者
Le Wang,Jiancheng Dong,Hong Chuang Song,Kai Ze Shen,Li Mei Wang,Rong Sun,Chun Ren Wang,Guo Hong Li,Lei Li,Ke Qin Zhang
摘要
The EtOAc extracts of cultural filtrates of 30 freshwater fungi were assayed for thein vitro antibacterial activity againstBacillus cereus YMF 3.19,Brevibacillus laterosporus YMF 3.08,Escherichia coli YMF 3.16,Staphylococcus aureus YMF 3.17 using the disc diffusion method. A total of 14 fungal strains displayed active against all of the bacteria tested and the strongest antibacterial activity was recorded inCamposporium quercicola YMF1.01300 isolate. Extraction of fermentation broth ofC. quercicola YMF1.01300 and various separation and purification steps led to isolation of three pure active molecules. The chemical structures of these three compounds, a new diphenyl ether, named as quercilolin (compound1), as well as two previously known compounds, tenellic acid A (compound2), and 2′, 4′-dihydroxyacetophenone (compound3), were established by analysis of NMR and MS data, and by comparison with reference data from the literature. These results indicate that some freshwater fungi could be a potential source of antibacterial agents.
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