长寿
转录因子
细胞生物学
果蝇属(亚属)
化学
生物
遗传学
基因
作者
Xiaolan Fan,Yao Zeng,Fan Ziqiang,Liang Cui,Wenhao Song,Qi Wu,Yue Gao,Deying Yang,Xueping Mao,Bo Zeng,Mingwang Zhang,Qingyong Ni,Yan Li,Tao Wang,Diyan Li,Mingyao Yang
出处
期刊:Aging
[Impact Journals, LLC]
日期:2021-01-15
卷期号:13 (1): 460-476
被引量:7
标识
DOI:10.18632/aging.202156
摘要
Drugs or compounds have been shown to promote longevity in various approaches. We used Drosophila to explore novel natural compounds can be applied to anti-aging. Here we reported that a flavonoid named Dihydromyricetin can increase stress that tolerance and lipid levels, slow down gut dysfunction and extend Drosophila lifespan. Dihydromyricetin can also lessen pERK and pAKT signaling, consequently activating FOXO and AOP to modulate longevity. Our results suggested that DHM could be used as an effective compound for anti-aging intervention, which could likely be applied to both mammals and humans.
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