葱
毛螺菌科
促炎细胞因子
结肠炎
化学
肠道菌群
炎症性肠病
消炎药
药理学
食品科学
白细胞介素
炎症
微生物学
生物化学
生物
内科学
植物
细胞因子
医学
免疫学
厚壁菌
疾病
基因
16S核糖体RNA
作者
Xin Shao,Chongzhen Sun,Xin Tang,Xiaosa Zhang,Didi Han,Shan Liang,Rong Qu,Xiaodan Hui,Yangwei Shan,Linhui Hu,Heng Fang,Huidan Zhang,Xiyang Wu,Chunbo Chen
标识
DOI:10.1021/acs.jafc.0c04773
摘要
Garlic polysaccharides are great potential agents because of their anti-inflammation, antioxidation, and immunomodulation properties. However, few studies have reported their anti-inflammatory effects on improving the colon system and corresponding intestinal microbiota. Herein, a water-soluble garlic polysaccharide (WSGP) was extracted from Jinxiang garlic to evaluate its effects on ameliorating dextran sulfate sodium (DSS)-induced colitis in a mouse model. The results showed that (1) after administration of the WSGP (200 or 400 mg/kg/day), the feed intake, body weight, and colon length of colitic mice were increased, while the disease activity index and the histological score of colitic mice were decreased; (2) the WSGP reduced the colonic tissue damage and inhibited the expression of inflammatory factors (interleukin 6, interleukin 1 beta , and tumor necrosis factor alpha); and (3) the WSGP enhanced the production of short-chain fatty acids and improved the composition of intestinal microbiota. The key microorganisms, including Muribaculaceae, Lachnospiraceae, Lachnospiraceae_NK4A136_group, Mucispirillum, Helicobacter, Ruminococcus_1, and Ruminiclostridium_5, were identified to be associated with inflammatory bowel diseases. Taken together, this study proved that WSGP supplementation could alleviate DSS-induced colitis by improving mucosal barriers, blocking proinflammatory cytokines, and modulating gut microbiota.
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