医学
银屑病
银屑病性关节炎
促炎细胞因子
皮肤病科
肿瘤坏死因子α
免疫学
人口
疾病
关节炎
类风湿性关节炎
生物制剂
炎症
内科学
环境卫生
作者
Meagan-Helen Henderson Berg,Daniel Carrasco
出处
期刊:PubMed
日期:2017-07-01
卷期号:16 (7): 695-698
被引量:6
摘要
Psoriasis is a chronic inflammatory cutaneous disease that affects 2-3% of the general population. Up to 30% of patients with psoriasis also develop psoriatic arthritis, a chronic inflammatory and progressive arthritis. Although their precise pathogeneses remain unclear, psoriasis and psoriatic arthritis involve altered expression of proinflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-12, IL-17, IL-22, and IL-23. The development of biologic agents that target these cytokines has greatly improved the treatment of psoriatic disease. Injection site reactions have been reported with many of these therapies. In this paper, we will present cases and review the literature on injection site reactions with the major biologic agents administered subcutaneously for the treatment of psoriasis and psoriatic arthritis. J Drugs Dermatol. 2017;16(7):695-698. .
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