生物
细菌
微生物学
生物膜
C型凝集素
凝集素
分段丝状菌
平衡
细胞生物学
免疫学
遗传学
污水处理
工程类
废物管理
活性污泥
作者
Yuxuan Zhang,Minglu Zhang,Xian‐Wei Wang
出处
期刊:Journal of Immunology
[American Association of Immunologists]
日期:2021-02-01
卷期号:206 (6): 1140-1150
被引量:25
标识
DOI:10.4049/jimmunol.2000116
摘要
Abstract Intestinal microbiota are closely related to host physiology. Over the long course of evolution and interaction, both commensal bacteria and their host have evolved multiple strategies to adapt to each other. However, in invertebrates, the regulatory mechanism of intestinal microbiota homeostasis is largely unknown. In the current study, a digestive tract–specific C-type lectin, designated as CTL33, was identified because of its abundance and response to bacteria in the intestine of kuruma shrimp (Marsupenaeus japonicus). Silencing of CTL33 expression led directly to intestinal dysbiosis, tissue damage, and shrimp death. CTL33 could facilitate biofilm formation by the intestinal bacteria. This function originated from its unique architecture, with a lectin domain responsible for bacteria recognition and a coiled coil region that mediated CTL33 dimerization and cross-linked the bacteria into a biofilm-like complex. By mediating the formation of a biofilm, CTL33 promoted the establishment of intestinal bacteria in intestine and maintained the homeostasis of the microbiota. Thus, to our knowledge, we demonstrated a new mechanism of C-type lectin–mediated biofilm formation by intestinal bacteria, providing new insights into intestinal homeostasis regulation in invertebrates.
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