化学
咔唑
支原体
抗菌剂
立体化学
链霉菌
枯草芽孢杆菌
白色念珠菌
海绵
细菌
金黄色葡萄球菌
微生物学
结核分枝杆菌
有机化学
肺结核
病理
生物
医学
植物
遗传学
作者
Yijia Cheng,Nannan Chen,Jing Li,Jun-Cheng Su,Jingya Yang,Cui‐Xian Zhang,Hou‐Wen Lin,Yongjun Zhou
标识
DOI:10.1002/cjoc.202000736
摘要
Main observation and conclusion Four new chlorinated carbazole alkaloids, chlocarbazomycins (CCBs) A—D, were isolated from sponge associated bacterium Streptomyces diacarni LHW51701. Their structures were elucidated via spectroscopic techniques (including HRESIMS, 1D & 2D NMR), and X‐ray crystallographic analysis. Structurally, the 4‐chloro coupled with 3‐methoxyl substituents in the tricycle nucleus of CCBs A—D and the N ‐methoxyl group of CCB‐D are rare in naturally occurred tricyclic carbazole alkaloids. Moreover, CCBs A—D do not bear the typical C1 para ‐alkyl and C2 meta ‐methyl side chains of bacterial tricycle carbazoles, suggesting a novel mechanism of aromatic ring formation in biosynthesis. The biological evaluation showed that CCB‐C possessed inhibitory activities against pathogenic microorganisms including methicillin‐resistant Staphylococcus aureus (MRSA), Mycobacterium smegmatis , Bacillus mycoides , and Candida albicans .
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