溃疡性结肠炎
结肠炎
炎症性肠病
炎症
透明质酸
势垒函数
医学
肠粘膜
发病机制
灌肠
免疫学
肠道通透性
肠上皮
上皮
病理
生物
疾病
内科学
细胞生物学
解剖
作者
Niranjan G. Kotla,Isma Liza Mohd Isa,Swetha Rasala,Seçil Demir,Rajbir Singh,Becca V. Baby,Samantha Swamy,Peter Dockery,Venkatakrishna R. Jala,Yury Rochev,Abhay Pandit
标识
DOI:10.1002/advs.202103189
摘要
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standard therapeutic interventions for colitis have focused mainly on maintaining the remission levels of the disease. Nonetheless, such treatment strategies (using anti-inflammatory, immunomodulatory agents) do not address colitis' root cause, especially the mucosal damage and dysregulated intestinal barrier functions. Restoration of barrier functionality by mucosal healing or physical barrier protecting strategies shall be considered as an initial event in the disease suppression and progression. Herein, a biphasic hyaluronan (HA) enema suspension, naïve-HA systems that protect the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate-induced colitis mice model is reported. Furthermore, HA-based system modulates intestinal epithelial junctional proteins and regulatory signaling pathways, resulting in attenuation of inflammation and mucosal protection. The results suggest that HA-based system can be delivered as an enema to act as a barrier protecting system for managing distal colonic inflammatory diseases, including colitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI