蛋白质组
药品
计算生物学
药物发现
仿形(计算机编程)
化学
药理学
生物信息学
生物
计算机科学
操作系统
作者
André Mateus,Nils Kurzawa,Jessica Perrin,Giovanna Bergamini,Mikhail M. Savitski
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2022-01-06
卷期号:62 (1): 465-482
被引量:33
标识
DOI:10.1146/annurev-pharmtox-052120-013205
摘要
Drug target deconvolution can accelerate the drug discovery process by identifying a drug's targets (facilitating medicinal chemistry efforts) and off-targets (anticipating toxicity effects or adverse drug reactions). Multiple mass spectrometry-based approaches have been developed for this purpose, but thermal proteome profiling (TPP) remains to date the only one that does not require compound modification and can be used to identify intracellular targets in living cells. TPP is based on the principle that the thermal stability of a protein can be affected by its interactions. Recent developments of this approach have expanded its applications beyond drugs and cell cultures to studying protein-drug interactions and biological phenomena in tissues. These developments open up the possibility of studying drug treatment or mechanisms of disease in a holistic fashion, which can result in the design of better drugs and lead to a better understanding of fundamental biology.
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