代谢物
化学
生化工程
代谢物分析
纳米技术
材料科学
生物化学
工程类
作者
Anil Koklu,David Ohayon,Shofarul Wustoni,Victor Druet,Abdulelah Saleh,Sahika Inal
出处
期刊:Chemical Reviews
[American Chemical Society]
日期:2021-10-05
卷期号:122 (4): 4581-4635
被引量:29
标识
DOI:10.1021/acs.chemrev.1c00395
摘要
Electrochemical detection of metabolites is essential for early diagnosis and continuous monitoring of a variety of health conditions. This review focuses on organic electronic material-based metabolite sensors and highlights their potential to tackle critical challenges associated with metabolite detection. We provide an overview of the distinct classes of organic electronic materials and biorecognition units used in metabolite sensors, explain the different detection strategies developed to date, and identify the advantages and drawbacks of each technology. We then benchmark state-of-the-art organic electronic metabolite sensors by categorizing them based on their application area (in vitro, body-interfaced, in vivo, and cell-interfaced). Finally, we share our perspective on using organic bioelectronic materials for metabolite sensing and address the current challenges for the devices and progress to come.
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