医学
成像生物标志物
脑出血
芯(光纤)
内科学
放射科
冲程(发动机)
薄壁组织
心脏病学
生物标志物
缺血性中风
磁共振成像
缺血
病理
蛛网膜下腔出血
复合材料
化学
材料科学
工程类
机械工程
生物化学
作者
Yiqi Wang,Peng Wang,Sheng Zhang,Zongjie Shi,Min Jiao,Geng Yang
标识
DOI:10.1016/j.jstrokecerebrovasdis.2021.106125
摘要
Recently studies have shown that select acute ischemic stroke (AIS) patients with large ischemic core could be deemed as reasonable candidates to receive mechanical thrombectomy (MT) with low risk of developing parenchymal hemorrhage (PH) or symptomatic intracerebral hemorrhage (sICH); however, the selection criterion remains lacking. Our study aims to investigate the relationship between a novel imaging biomarker of largest core mass volume (LCMV) and development of PH in stroke patients with large ischemic core who have undergone MT.A total of 26 AIS patients with large ischemic core (defined as ischemic core volume ≧ 50 ml) were enrolled in the study. Volume of ischemic core and the LCMV measured with Mistar software were measured in all patients. Fourteen patients with AIS developed PH while 12 patients showed no signs of PH based on CT imaging obtained between 24 h and 3 day after MT. We compared the volume of ischemic core and LCMV between two groups.Volume of ischemic core showed no significant difference between the PH and no PH group [105.5 (62.4-131.5) vs 75.0 (56.3-102.2), p = 0.105], whereas LCMV was significantly higher in the PH (14.80 ± 5.23) vs. no PH group (8.40 ± 2.61, p = 0.001). ROC analysis revealed that LCMV was positively correlated with PH (area under the curve = 0.905). The optimal LCMV associated with PH was ≧ 9.67 ml.LCMV is an effective and easy-to-use imaging biomarker to predict PH after MT in AIS patients with large ischemic core.
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