Comparison of Outcomes between Obese and Nonobese Patients in Laparoscopic Adrenalectomy: A Cohort Study

<b><i>Introduction:</i></b> Obesity is usually considered a risk factor for surgical complications. Laparoscopic adrenalectomy has replaced open adrenalectomy as the standard operation for adrenal tumors. <b><i>Objective:</i></b> To compare the safety of laparoscopic adrenalectomy to treat adrenal tumors in obese versus nonobese patients. <b><i>Methods:</i></b> This observational cohort study analyzed consecutive patients who underwent laparoscopic adrenalectomy with a lateral transperitoneal approach at a single center (2003–2020). Data and outcomes of obese (body mass index ≥30 kg/m²) and nonobese patients were compared. To analyze the association between operative time and other variables, we used simple and multivariate linear regression. <b><i>Results:</i></b> <i>N</i> = 160 (90 obese/70 nonobese) patients underwent laparoscopic adrenalectomy. Cushing syndrome and pheochromocytoma were the most frequent indications. Obese patients were older (58 vs. 52 years, <i>p</i> &#x3c; 0.001). A greater proportion of obese patients were ASA grade III + IV (71.1 vs. 48.6%, <i>p</i> = 0.004). Obesity was associated with a longer operative time (72.5 vs. 60 min, <i>p</i> &#x3c; 0.001) and greater blood loss (40 vs. 20 mL, <i>p</i> = 0.022). There were no differences in conversion, morbidity, or hospital stay. After adjustment for confounding factors, operative time was positively correlated with BMI ≥30 kg/m², learning curve, estimated blood loss, 2D laparoscopy, and specimen size. <b><i>Conclusion:</i></b> Lateral transperitoneal laparoscopic adrenalectomy is safe in patients with a BMI 30–35 kg/m², so these patients also benefit from this minimally invasive surgery.