奥沙利铂
光热治疗
肿瘤微环境
癌症研究
肝细胞癌
药物输送
体内
材料科学
热疗
活性氧
体外
纳米技术
化学
癌症
医学
生物
结直肠癌
肿瘤细胞
生物化学
生物技术
内科学
作者
Run Huang,Weiren Liu,Qinghao Zhang,Gui‐Qi Zhu,Wei‐Feng Qu,Chenyang Tao,Jun Gao,Yuan Fang,Xiu–Tao Fu,Ji Zhou,Ying–Hong Shi,Jia Fan,Zheng Tang
标识
DOI:10.1021/acsami.2c19305
摘要
The activation of nanoparticles (NPs) in the tumor microenvironment exerts synergistic therapeutic effects with chemotherapy against multiple cancers. In this study, an NP system prepared using biocompatible MIL-100 NPs was studied as an effective vehicle to deliver oxaliplatin for hepatocellular carcinoma treatment. The NPs were coated with polydopamine (PDA) and NH2-PEGTK-COOH and then loaded with oxaliplatin to create the multi-functional NP Oxa@MIL-PDA-PEGTK. Oxa@MIL-PDA-PEGTK is activated in the tumor microenvironment, causing the generation of cytotoxic reactive oxygen species (ROS) via the Fenton reaction and the release of the loaded oxaliplatin. In addition, under near-infrared (NIR) irradiation, Oxa@MIL-PDA-PEGTK can generate hyperthermia at tumor sites. Moreover, owing to the light-induced activation of the Oxa@MIL-PDA-PEGTK NPs, higher drug delivery efficiency, more precise targeted activation, and reduced off-target toxicity were observed in in vitro and in vivo experiments. Taken together, owing to its improved drug delivery efficiency and multi-functional activities, including the ability for targeted chemotherapy coupled with photothermal and chemodynamic therapy, Oxa@MIL-PDA-PEGTK may serve as a new approach for treating hepatocellular carcinoma.
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