色氨酸
转化(遗传学)
纤维类型
化学
肌肉纤维
纤维
膳食纤维
生物
食品科学
细胞生物学
生物化学
解剖
骨骼肌
氨基酸
基因
有机化学
作者
Taigang He,Zhidong Yuan,Qing‐Yun Chen,Jianxun Luo,Jian Mao,Zhiru Tang,Xuan Zhang,Zhenlan Yang
标识
DOI:10.1021/acs.jafc.4c00762
摘要
The nutritional composition of the diet significantly impacts the overall growth and development of weaned piglets. The current study aimed to explore the effects and underlying mechanisms of dietary tryptophan consumption on muscle fiber type transformation during the weaning period. Thirty weaned piglets with an average body weight of 6.12 ± 0.16 kg were randomly divided into control (CON, 0.14% Trp diet) and high Trp (HT, 0.35% Trp) groups and maintained on the respective diet for 28 days. The HT group of weaned piglets exhibited highly significant improvements in growth performance and an increased proportion of fast muscle fibers. Transcriptome sequencing revealed the potential contribution of differentially expressed circular RNAs toward the transformation of myofiber types in piglets and toward the regulation of expression of related genes by targeting the microRNAs, miR-34c and miR-182, to further regulate myofiber transformation. In addition, 145 DE circRNAs were identified as potentially protein-encoding, with the encoded proteins associated with a myofiber type transformation. In conclusion, the current study greatly advances and refines our current understanding of the regulatory networks associated with piglet muscle development and myofiber type transformation and also contributes to the optimization of piglet diet formulation.
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