抗抑郁药
氯胺酮
NMDA受体
突触可塑性
神经科学
药理学
信号转导
海马体
医学
生物
受体
内科学
细胞生物学
作者
Ji Woon Kim,Kanzo Suzuki,Ege T. Kavalali,Lisa M. Monteggia
标识
DOI:10.1016/j.molmed.2023.02.003
摘要
Acute administration of (R,S)-ketamine (ketamine) produces rapid antidepressant effects that in some patients can be sustained for several days to more than a week. Ketamine blocks N-methyl-d-asparate (NMDA) receptors (NMDARs) to elicit specific downstream signaling that induces a novel form of synaptic plasticity in the hippocampus that has been linked to the rapid antidepressant action. These signaling events lead to subsequent downstream transcriptional changes that are involved in the sustained antidepressant effects. Here we review how ketamine triggers this intracellular signaling pathway to mediate synaptic plasticity which underlies the rapid antidepressant effects and links it to downstream signaling and the sustained antidepressant effects.
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