层状双氢氧化物
材料科学
双金属片
检出限
电化学气体传感器
纳米传感器
电化学
氢氧化物
纳米技术
化学工程
化学
电极
色谱法
金属
冶金
物理化学
工程类
作者
Jiameng Liu,Zheng Tao,Yinpeng Zhang,Tianjun Ni,Baozhong Liu,Zhihong Zhang
标识
DOI:10.1016/j.microc.2023.109757
摘要
Based on the heterojunction of V2CTx MXene and bimetallic CoNi-layered double hydroxide (CoNi-MLDH), a novel dual-modal electrochemical aptasensor (denoted as CoNi-MLDH@V2CTx) was developed for the noninvasive point-of-care detection of cortisol in different body fluids (such as sweat, urine, and blood). Herein, V2CTx nanosheets (NSs) were used as scaffolds for the in-situ growth of cobalt/nickel zeolitic imidazolate framework (CoNi-ZIF) polyhedrons, which was then converted to CoNi-MLDH NSs through an in situ etching–coprecipitating process. Benefiting from the merits of V2CTx NSs (excellent electrochemical activity) and CoNi-ZIF (large specific surface and pore size, rich functionality, excellent oxygen reduction, and strong bioaffinity toward aptamer), and from the synergistic effect, the CoNi-LDH@V2CTx junction showed great potential as a platform for the constructing the electrochemical aptasensor for detecting cortisol. Within a wide cortisol range 10 fg mL−1 to 100 ng mL−1, the dual-modal impedimetric and zinc-air battery-driven self-powered aptasensor based on CoNi-MLDH@V2CTx illustrated the ultralow detection limit of cortisol, 0.26 and 0.17 fg mL−1, respectively. They demonstrated high selectivity, superior stability, excellent reproducibility, and promising regeneration ability, and showed potential applications for cortisol analysis in different environments (sweat, urine, and blood). The present work provides a promising option for maintaining people’s mental health through the sensitive and selective detection of cortisol in human fluids.
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