化学
废止
降冰片烯
芳基
钯
催化作用
酰化
组合化学
药物化学
脱羧
有机化学
单体
聚合物
烷基
作者
Liwei Zhou,Pengyang Jing,Zhiwei Li,Rui Li,Jiannan Chen,Guobo Deng,Yun Liang,Yuan Yang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-01-18
卷期号:26 (3): 676-680
被引量:1
标识
DOI:10.1021/acs.orglett.3c04065
摘要
A palladium-catalyzed divergent cascade decarboxylative annulation of aryl iodides and α-oxocarboxylic acids using norbornene (NBE) derivatives as a controlled switch is reported. When NBE is used as a mediator, fluorenones are synthesized with moderate to excellent yields via a Catellani reaction that involves sequential ortho-C–H arylation and ipso-decarboxylative acylation of aryl iodides. Employing oxanorbornadiene (ONBD) instead of NBE enables the assembly of dibenzo[a,c]cycloheptenones by a retro-Diels–Alder reaction rather than the release of an ONBD. Additionally, the synthetic utility of this method is demonstrated by the diversification of the products.
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