Natural Cell Patches: Melanin Nanoparticles for MR Imaging‐Guided Antiatherosclerosis Therapy via Attenuating Macrophage Pyroptosis (Adv. Funct. Mater. 13/2023)

Natural Cell Patches In article number 2212748, Longjiang Zhang and co-workers report a multifunctional nanoplatform cRGD-PEG-MNP (RpMP). RpMPs act like cell patches to suppress macrophage pyroptosis, thus potently ameliorating the development of atherosclerosis via targeting plaque neovascularization. Chelator-free Gd3+-RpMPs exhibit persistent T1-weighted contrast-enhanced efficiency and plaque resident on a 9.4 T Micro MR scanner. The presented nanoplatform possesses the potential for molecular theranostic in pyroptosis-related diseases.