腰围
性激素结合球蛋白
医学
全国健康与营养检查调查
体质指数
睾酮(贴片)
周长
内科学
肥胖
混淆
内分泌学
腹部肥胖
人口学
激素
雄激素
人口
环境卫生
几何学
社会学
数学
作者
Zhongyuan Wang,Bao-Chao Li,Jia-Jun Xing,Shouyong Liu,Tong-Tong Zhang,Aiming Xu,Zengjun Wang
摘要
In the recent decades, obesity rates among children and adolescents, especially males, have increased significantly. This worldwide phenomenon is thought to significantly affect the levels of sex hormones. However, the association between waist circumference (a marker of abdominal obesity) and sex hormone levels in children and adolescents is unknown. In this study, 4031 participants aged 6–19 years from the United States National Health and Nutrition Examination Survey (NHANES) in the USA were enrolled in this study. The common confounders of age, race, body mass index, educational level, family income, diabetes, and time of sample collection were also collected. The participants missing any of the above information were excluded from the study. We used multiple linear regression and other multiple statistics to assess the associations between waist circumference and serum testosterone, estradiol, sex hormone-binding globulin (SHBG), free androgen index (FAI), and testosterone/estradiol ratio (T/E 2 ). Waist circumference remained associated with sex hormone levels in children and adolescents after controlling for covariates. As waist circumference increases, testosterone levels in children and adolescents show an overall decline after a brief increase, with the inflection point for waist circumference of 65–66 cm. In addition, waist circumference positively correlates with estradiol levels in male children ( β = 0.007, 95% confidence interval: 0.004–0.009). Moreover, circulating SHBG decreases in children and adolescents as waist circumference increases. In conclusion, this study highlighted waist circumference as a vital indicator affecting sex hormone levels in children and adolescents.
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