纳米颗粒
日冕(行星地质学)
血液蛋白质类
生物物理学
材料科学
白蛋白
纳米材料
纳米技术
化学
生物化学
物理
生物
天体生物学
维纳斯
作者
Susannah Emily Cornwell,Sarah Ogechukwu Okocha,Enrico Ferrari
出处
期刊:Nanomaterials
[MDPI AG]
日期:2023-11-04
卷期号:13 (21): 2901-2901
摘要
When nanoparticles are introduced into the bloodstream, plasma proteins accumulate at their surface, forming a protein corona. This corona affects the properties of intravenously administered nanomedicines. The firmly bound layer of plasma proteins in direct contact with the nanomaterial is called the "hard corona". There is also a "soft corona" of loosely associated proteins. While the hard corona has been extensively studied, the soft corona is less understood due to its inaccessibility to analytical techniques. Our study used dynamic light scattering to determine the dissociation constant and thickness of the protein corona formed in solutions of silica or gold nanoparticles mixed with serum albumin, transferrin or prothrombin. Multivariate analysis showed that the nanoparticle material had a greater impact on binding properties than the protein type. Serum albumin had a distinct binding pattern compared to the other proteins tested. This pilot study provides a blueprint for future investigations into the complexity of the soft protein corona, which is key to developing nanomedicines.
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