Highly diastereo- and enantioselective synthesis of spiro β-lactams via copper-catalyzed Kinugasa/aldol cascade reaction

A copper( i )-catalyzed highly diastereo- and enantioselective Kinugasa/aldol cascade reaction of N -(2-acylaryl) propiolamides with nitrones has been demonstrated for efficient synthesis of structurally novel chiral spiro β-lactams.