横断面研究
病毒学
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
2019年冠状病毒病(COVID-19)
微生物群
糖尿病
2019-20冠状病毒爆发
医学
肠道微生物群
生物
Sars病毒
倍他科诺病毒
免疫学
疾病
内科学
生物信息学
传染病(医学专业)
爆发
病理
内分泌学
作者
Adnan Mannan,M. Nazmul Hoque,Sajjad Hossain Noyon,Hasan Mehedi,Javed Foisal,Asma Salauddin,Saiful Islam,Farjana Sharmen,Afroza Akter Tanni,Amam Zonaed Siddiki,Chin Yen Tay,Moradul Siddique,M. Shaminur Rahman,Syed Md Galib,Farhana Akter
摘要
Populations of different South Asian nations including Bangladesh reportedly have a high risk of developing diabetes in recent years. This study aimed to investigate the differences in the gut microbiome of COVID-19-positive participants with or without type 2 diabetes mellitus (T2DM) compared with healthy control subjects. Microbiome data of 30 participants with T2DM were compared with 22 age-, sex-, and body mass index (BMI)-matched individuals. Clinical features were recorded while fecal samples were collected aseptically from the participants. Amplicon-based (16S rRNA) metagenome analyses were employed to explore the dysbiosis of gut microbiota and its correlation with genomic and functional features in COVID-19 patients with or without T2DM. Comparing the detected bacterial genera across the sample groups, 98 unique genera were identified, of which 9 genera had unique association with COVID-19 T2DM patients. Among different bacterial groups, Shigella (25%), Bacteroides (23.45%), and Megamonas (15.90%) had higher mean relative abundances in COVID-19 patients with T2DM. An elevated gut microbiota dysbiosis in T2DM patients with COVID-19 was observed while some metabolic functional changes correlated with bidirectional microbiome dysbiosis between diabetes and non-diabetes humans gut were also found. These results further highlight the possible association of COVID-19 infection that might be linked with alteration of gut microbiome among T2DM patients.
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