免疫原性细胞死亡
免疫疗法
肿瘤微环境
癌症免疫疗法
光热治疗
癌症研究
活性氧
光化学
材料科学
光动力疗法
羟基自由基
催化作用
免疫系统
化学
激进的
医学
纳米技术
肿瘤细胞
免疫学
生物化学
有机化学
作者
Qianqian Zhang,Li Yang,Chunhuan Jiang,Wenbo Sun,Jingwei Tao,Lehui Lu
标识
DOI:10.1002/adhm.202301502
摘要
Hydroxyl radical (• OH) as a highly oxidizing reactive oxygen species can induce immunogenic cell death (ICD) in cancer treatment. However, high-efficiency cancer immunotherapy is still a huge challenge due to the low • OH generation efficiency in the tumor microenvironment, resulting in insufficient immunogenicity and the poor immune response. Here, a near-infrared (NIR) light-enhanced • OH generation strategy is developed for cancer immunotherapy by using a copper-based metal-organic framework (Cu-DBC) nanoplatform. With this strategy, the generation efficiency of • OH under NIR irradiation is increased 7.34 times than that without NIR irradiation, which induces robust ICD and immune response, thus leading to primary tumor elimination and the inhibition of distant tumor growth and tumor lung metastasis. Experimental results show that Cu-DBC can induce • OH boosting through photothermal (PT)-enhanced Cu-catalytic Fenton-like reaction and photocatalytic electron transfer under NIR light irradiation to amplify tumor ICD for immunotherapy.
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