Insights into the role of N6-methyladenosine in ferroptosis

N6-methyladenosine (m⁶A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m⁶A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis is an iron-dependent cell death characterized by excessive lipid peroxidation. Emerging evidence supports that ferroptosis has a significant role in the progression of diverse diseases. Besides, the key regulators of ferroptosis exhibit aberrant m⁶A levels under different pathological conditions. However, the correlation between m⁶A-modified ferroptosis and multiple diseases has not been well elucidated. In this review, we summarized the functions of m⁶A in ferroptosis, which are associated with the initiation and progression of multiple diseases. Investigating the role of m⁶A in ferroptosis might both facilitate a better understanding of the pathogenesis of these diseases and provide new opportunities for targeted treatment.