N6-甲基腺苷
RNA甲基化
表观遗传学
甲基化
生物
程序性细胞死亡
核糖核酸
DNA甲基化
疾病
发病机制
甲基转移酶
细胞生物学
医学
遗传学
基因
基因表达
细胞凋亡
免疫学
病理
作者
Jingyuan Zhang,Tianming Qiu,Xiaofeng Yao,Xiance Sun
标识
DOI:10.1016/j.biopha.2023.115192
摘要
N6-methyladenosine (m6A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m6A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis is an iron-dependent cell death characterized by excessive lipid peroxidation. Emerging evidence supports that ferroptosis has a significant role in the progression of diverse diseases. Besides, the key regulators of ferroptosis exhibit aberrant m6A levels under different pathological conditions. However, the correlation between m6A-modified ferroptosis and multiple diseases has not been well elucidated. In this review, we summarized the functions of m6A in ferroptosis, which are associated with the initiation and progression of multiple diseases. Investigating the role of m6A in ferroptosis might both facilitate a better understanding of the pathogenesis of these diseases and provide new opportunities for targeted treatment.
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