已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The CLIP1 – LTK fusion: anew oncogenic driver in non-small-cell lung cancer?

肺癌 医学 肿瘤科 癌症 内科学
作者
Rebecca Ibrahim,Claude Chahine,Tony Felefly,Nadine Khalife,Khalil Saleh
出处
期刊:Future Oncology [Future Medicine]
卷期号:19 (4): 273-275 被引量:2
标识
DOI:10.2217/fon-2022-1232
摘要

Future OncologyAhead of Print EditorialThe CLIP1–LTK fusion: A new oncogenic driver in non-small-cell lung cancer?Rebecca Ibrahim, Claude Chahine, Tony Felefly, Nadine Khalife & Khalil SalehRebecca IbrahimInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author, Claude ChahineInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author, Tony FeleflyRadiation Oncology Department, Saint-Joseph University, Beyrouth, 1100, LebanonSearch for more papers by this author, Nadine KhalifeDepartment of Head & Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author & Khalil Saleh *Author for correspondence: Tel.: +33 142 114 211; E-mail Address: khalil_saleh@live.comhttps://orcid.org/0000-0002-2985-2202International Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this authorPublished Online:21 Mar 2023https://doi.org/10.2217/fon-2022-1232AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ALK fusionCLIP1-LTK fusionlorlatinibnon-small-cell lung cancertyrosine kinase inhibitorsReferences1. Guo H, Zhang J, Qin C et al. Biomarker-targeted therapies in non-small cell lung cancer: current status and perspectives. Cells 11(20), 3200 (2022).Crossref, Medline, CAS, Google Scholar2. Howlader N, Forjaz G, Mooradian MJ et al. The effect of advances in lung-cancer treatment on population mortality. N. Engl. J. Med. 383(7), 640–649 (2020).Crossref, Medline, CAS, Google Scholar3. Soria J-C, Ohe Y, Vansteenkiste J et al. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung cancer. N. Engl. J. Med. 378(2), 113–125 (2018).Crossref, Medline, CAS, Google Scholar4. Kwak EL, Bang Y-J, Camidge DR et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363(18), 1693–1703 (2010).Crossref, Medline, CAS, Google Scholar5. Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 417(6892), 949–954 (2002).Crossref, Medline, CAS, Google Scholar6. Paik PK, Drilon A, Fan P-D et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov. 5(8), 842–849 (2015).Crossref, Medline, CAS, Google Scholar7. Farago AF, Taylor MS, Doebele RC et al. Clinicopathologic features of non-small-cell lung cancer harboring an NTRK gene fusion. JCO Precis. Oncol. 2018, PO.18.00037 (2018).Medline, Google Scholar8. Tsuta K, Kohno T, Yoshida A et al. RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis. Br. J. Cancer 110(6), 1571–1578 (2014).Crossref, Medline, CAS, Google Scholar9. Gautschi O, Milia J, Filleron T et al. Targeting RET in patients with RET-rearranged lung cancers: results from the Global, Multicenter RET Registry. J. Clin. Oncol. 35(13), 1403–1410 (2017).Crossref, Medline, CAS, Google Scholar10. Kim HR, Lim SM, Kim HJ et al. The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma. Ann. Oncol. 24(9), 2364–2370 (2013).Crossref, Medline, CAS, Google Scholar11. Chevallier M, Borgeaud M, Addeo A, Friedlaender A. Oncogenic driver mutations in non-small cell lung cancer: past, present and future. World J. Clin. Oncol. 12(4), 217–237 (2021).Crossref, Medline, Google Scholar12. Izumi H, Matsumoto S, Liu J et al. The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer. Nature 600(7888), 319–323 (2021).Crossref, Medline, CAS, Google Scholar13. Roll JD, Reuther GW. ALK-activating homologous mutations in LTK induce cellular transformation. PLOS ONE 7(2), e31733 (2012).Crossref, Medline, CAS, Google Scholar14. Ben-Neriah Y, Bauskin AR. Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. Nature 333(6174), 672–676 (1988).Crossref, Medline, CAS, Google Scholar15. Kozutsumi H, Toyoshima H, Hagiwara K et al. Identification of the human ltk gene product in placenta and hematopoietic cell lines. Biochem. Biophys. Res. Commun. 190(2), 674–679 (1993).Crossref, Medline, CAS, Google Scholar16. Bernards A, de la Monte SM. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 9(7), 2279–2287 (1990).Crossref, Medline, CAS, Google Scholar17. Müller-Tidow C, Schwäble J, Steffen B et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin. Cancer Res. 10(4), 1241–1249 (2004).Crossref, Medline, CAS, Google Scholar18. Lin JJ, Shaw AT. Recent advances in targeting ROS1 in lung cancer. J. Thorac. Oncol. 12(11), 1611–1625 (2017).Crossref, Medline, Google Scholar19. Toyokawa G, Seto T. Updated evidence on the mechanisms of resistance to ALK Inhibitors and strategies to overcome such resistance: clinical and preclinical data. Oncol. Res. Treat. 38(6), 291–298 (2015).Crossref, Medline, CAS, Google Scholar20. Robert NJ, Nwokeji ED, Espirito JL et al. Biomarker tissue journey among patients (pts) with untreated metastatic non-small cell lung cancer (mNSCLC) in the U.S. Oncology Network community practices. J. Clin. Oncol. 39(Suppl. 15), 9004–9004 (2021).Crossref, Google ScholarFiguresReferencesRelatedDetails Ahead of Print eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 19 times History Received 7 December 2022 Accepted 25 January 2023 Published online 21 March 2023 Information© 2023 Future Medicine LtdKeywordsALK fusionCLIP1-LTK fusionlorlatinibnon-small-cell lung cancertyrosine kinase inhibitorsFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
大模型应助zhoudada采纳,获得10
刚刚
科研通AI6.4应助zhoudada采纳,获得10
刚刚
英俊的铭应助zhoudada采纳,获得10
刚刚
LUOCC应助ygy采纳,获得30
2秒前
2秒前
3秒前
迅速西装完成签到,获得积分10
5秒前
闪闪花生发布了新的文献求助10
5秒前
5秒前
5秒前
Li完成签到,获得积分20
6秒前
Aicy1111111发布了新的文献求助30
6秒前
xrwwww关注了科研通微信公众号
7秒前
陈平安发布了新的文献求助10
7秒前
guagua发布了新的文献求助10
8秒前
神勇映雁应助Dickson采纳,获得10
8秒前
万能图书馆应助zhoudada采纳,获得10
8秒前
852应助zhoudada采纳,获得10
8秒前
9秒前
Ava应助zhoudada采纳,获得10
9秒前
科研通AI6.2应助zhoudada采纳,获得10
9秒前
礼礼完成签到 ,获得积分10
9秒前
在水一方应助zhoudada采纳,获得10
9秒前
深情安青应助zhoudada采纳,获得10
9秒前
传奇3应助zhoudada采纳,获得10
10秒前
小马甲应助zhoudada采纳,获得10
10秒前
bkagyin应助zhoudada采纳,获得10
10秒前
科研通AI6.4应助zhoudada采纳,获得10
10秒前
12秒前
12秒前
13秒前
认真的小虾米完成签到 ,获得积分10
14秒前
15秒前
16秒前
川絮完成签到,获得积分10
19秒前
20秒前
丘比特应助谨慎的念云采纳,获得10
21秒前
kukudekun发布了新的文献求助20
21秒前
Yang完成签到,获得积分10
22秒前
林好事完成签到 ,获得积分10
22秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Principles of town planning: translating concepts to applications 1000
Management and the Arts 510
Matrix Methods in Data Mining and Pattern Recognition Second Edition 510
核安全综合知识2024版 500
Photothermal Science and Techniques 500
Digital Displacement Hydrostatic Transmission for Rotorcraft and Distributed Propulsion 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 内科学 物理 复合材料 催化作用 细胞生物学 无机化学 光电子学 物理化学 电极 基因
热门帖子
关注 科研通微信公众号,转发送积分 7710954
求助须知:如何正确求助?哪些是违规求助? 9267484
关于积分的说明 20066150
捐赠科研通 7287284
什么是DOI,文献DOI怎么找? 3297088
关于科研通互助平台的介绍 2451583
邀请新用户注册赠送积分活动 2304165