The CLIP1 – LTK fusion: anew oncogenic driver in non-small-cell lung cancer?

肺癌 医学 肿瘤科 癌症 内科学
作者
Rebecca Ibrahim,Claude Chahine,Tony Felefly,Nadine Khalife,Khalil Saleh
出处
期刊:Future Oncology [Future Medicine]
卷期号:19 (4): 273-275 被引量:2
标识
DOI:10.2217/fon-2022-1232
摘要

Future OncologyAhead of Print EditorialThe CLIP1–LTK fusion: A new oncogenic driver in non-small-cell lung cancer?Rebecca Ibrahim, Claude Chahine, Tony Felefly, Nadine Khalife & Khalil SalehRebecca IbrahimInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author, Claude ChahineInternational Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author, Tony FeleflyRadiation Oncology Department, Saint-Joseph University, Beyrouth, 1100, LebanonSearch for more papers by this author, Nadine KhalifeDepartment of Head & Neck Oncology, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this author & Khalil Saleh *Author for correspondence: Tel.: +33 142 114 211; E-mail Address: khalil_saleh@live.comhttps://orcid.org/0000-0002-2985-2202International Department, Gustave Roussy Cancer Campus, Villejuif, 94800, FranceSearch for more papers by this authorPublished Online:21 Mar 2023https://doi.org/10.2217/fon-2022-1232AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: ALK fusionCLIP1-LTK fusionlorlatinibnon-small-cell lung cancertyrosine kinase inhibitorsReferences1. 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Oncol. 24(9), 2364–2370 (2013).Crossref, Medline, CAS, Google Scholar11. Chevallier M, Borgeaud M, Addeo A, Friedlaender A. Oncogenic driver mutations in non-small cell lung cancer: past, present and future. World J. Clin. Oncol. 12(4), 217–237 (2021).Crossref, Medline, Google Scholar12. Izumi H, Matsumoto S, Liu J et al. The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer. Nature 600(7888), 319–323 (2021).Crossref, Medline, CAS, Google Scholar13. Roll JD, Reuther GW. ALK-activating homologous mutations in LTK induce cellular transformation. PLOS ONE 7(2), e31733 (2012).Crossref, Medline, CAS, Google Scholar14. Ben-Neriah Y, Bauskin AR. Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain. Nature 333(6174), 672–676 (1988).Crossref, Medline, CAS, Google Scholar15. Kozutsumi H, Toyoshima H, Hagiwara K et al. Identification of the human ltk gene product in placenta and hematopoietic cell lines. Biochem. Biophys. Res. Commun. 190(2), 674–679 (1993).Crossref, Medline, CAS, Google Scholar16. Bernards A, de la Monte SM. The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator. EMBO J. 9(7), 2279–2287 (1990).Crossref, Medline, CAS, Google Scholar17. Müller-Tidow C, Schwäble J, Steffen B et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin. Cancer Res. 10(4), 1241–1249 (2004).Crossref, Medline, CAS, Google Scholar18. Lin JJ, Shaw AT. Recent advances in targeting ROS1 in lung cancer. J. Thorac. Oncol. 12(11), 1611–1625 (2017).Crossref, Medline, Google Scholar19. Toyokawa G, Seto T. Updated evidence on the mechanisms of resistance to ALK Inhibitors and strategies to overcome such resistance: clinical and preclinical data. Oncol. Res. Treat. 38(6), 291–298 (2015).Crossref, Medline, CAS, Google Scholar20. Robert NJ, Nwokeji ED, Espirito JL et al. Biomarker tissue journey among patients (pts) with untreated metastatic non-small cell lung cancer (mNSCLC) in the U.S. Oncology Network community practices. J. Clin. Oncol. 39(Suppl. 15), 9004–9004 (2021).Crossref, Google ScholarFiguresReferencesRelatedDetails Ahead of Print eToC Sign up Follow us on social media for the latest updates Metrics Downloaded 19 times History Received 7 December 2022 Accepted 25 January 2023 Published online 21 March 2023 Information© 2023 Future Medicine LtdKeywordsALK fusionCLIP1-LTK fusionlorlatinibnon-small-cell lung cancertyrosine kinase inhibitorsFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download
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