Sishen Pills Inhibit Inflammatory Dendritic Cell Differentiation via miR-505-3p mediated E-cadherin Downregulation in Ulcerative Colitis

Ulcerative colitis (UC) is an autoimmune disease that is highly susceptible to recurrence, which is still a lack of effective drugs with minor side effects in clinic. Intervention of inflammatory differentiation of dendritic cells (DCs) might be an effective strategy to treat UC. Sishen Pills (SSP) is a classic Chinese herbal formula which has been demonstrated the protective effect of UC, but the mechanism remains unclear.