Eyes on glutamate in angiogenesis and barrier formation

In this issue of Neuron, Biswas et al. 1 Biswas S. Shahriar S. Bachay G. Arvanitis P. Jamoul D. Brunken W.J. Agalliu D. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling. Neuron. 2024; 112: 1978-1996.e6https://doi.org/10.1016/j.neuron.2024.03.011 Abstract Full Text Full Text PDF Scopus (1) Google Scholar demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity. In this issue of Neuron, Biswas et al. 1 Biswas S. Shahriar S. Bachay G. Arvanitis P. Jamoul D. Brunken W.J. Agalliu D. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling. Neuron. 2024; 112: 1978-1996.e6https://doi.org/10.1016/j.neuron.2024.03.011 Abstract Full Text Full Text PDF Scopus (1) Google Scholar demonstrate the roles of glutamatergic neuronal activity in the regulation of angiogenesis and retinal vascular endothelial barrier maturation using three different knockout mouse models. Their findings shed light on how aberrant glutamatergic activity can impact neural vascular function and barrier integrity. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signalingBiswas et al.NeuronApril 9, 2024In BriefBiswas et al. demonstrate that glutamate released by retinal neurons induces Norrin expression in Müller glia and interneurons, promoting deep plexus angiogenesis and blood-retinal barrier maturation. These findings further our understanding of retinal vascular development and may help identify therapeutic targets for retinal pathologies where neuronal dysfunction precedes vascular pathologies. Full-Text PDF