Ménétrier Disease: A Scoping Review of Case Reports over the Last 10 Years

Abstract Objective This scoping review aims to map existing recent case reports on Menetrier’s disease examining clinical features, treatment strategies, potential etiological factors, and other associations to enhance understanding and inform future research directions. Methods We conducted a systematic search of PubMed, SCOPUS, Web of Science and Google Scholar for case reports on Menetrier’s disease published in English between January 2014 and October 2024. Eligible cases required histopathological confirmation, comprehensive clinical details, and unrestricted access, while pediatric cases and inaccessible records were excluded. Results Among 59 patients, 67.8% presented with Hypoalbuminemia, 37.3% were anemic. Regarding etiology, 20.3% tested positive for Helicobacter pylori suggesting a weaker link between the agent and Menetrier’s disease which highlights the need to explore other causes. 71.2% received pharmacological treatment of which 38% experienced full success, defined by both morphological and symptomatic improvements, while 66.6% experienced only symptomatic relief after treatment. Surgical Intervention was necessary for 35.6% of patients. The variability in clinical presentation and treatment outcomes, along with the lack of standardized approaches, implicate a need for further research to improve diagnostic and therapeutic strategies for Ménétrier’s disease. Conclusions This scoping review identifies critical research gaps in Ménétrier’s disease, including the need for further investigation into genetic predispositions, the role of etiological agents, treatment efficacy of emerging therapies, and the timing of surgical interventions, alongside the importance of cancer surveillance.