Asperhydrindane A, a new hydrindane derivate isolated from a mangrove-derived fungi Aspergillus terreus GXIMD 03158

A new hydrindane derivative, asperhydrindane A (1), along with two known sterol analogues [isocyathisterol (2) and ganodermasides D (3)] were isolated from the mangrove-derived fungus Aspergillus terreus GXIMD 03158 attaching to the mangrove Acanthus ilicifoius L. The structure of 1 was elucidated based on extensive spectral analysis, HRESIMS, and calculated ECD methods. All compounds were evaluated for antibacterial activity. The result showed that only compound 3 exhibited significant antibacterial activity against Staphylococcus aureus, Vibrio harveyi, and Vibrio parahaemolyticus with MIC values of 6.25, 3.12, and 1.56 μg/mL, respectively.