Cardiac dilation, energy stress, and ventricular remodeling: insights from prolonged voluntary exercise in male mice with TAC-induced HFpEF

As a self-initiating, self-sustaining, and low-cost treatment for patients with heart failure, how voluntary exercise plays its roles in interfering with the pathophysiologic pathways associated with HFpEF is still largely unknown. The results of this study indicate that long-term voluntary exercise can effectively antagonize acute and chronic dual-energy stress and avoid diastolic function limitation caused by pathological ventricular remodeling.