癌症干细胞
癌症研究
癌症
人口
生物
干细胞
类有机物
边居
干细胞标记物
癌细胞
PI3K/AKT/mTOR通路
细胞
MAPK/ERK通路
肿瘤进展
原发性肿瘤
细胞生长
病理
转移
肿瘤发生
医学
肿瘤细胞
作者
Hui Yi Grace Lim,Swathi Yada,Kazuhiro Murakami,Bernett Lee,Sowmya Sagiraju,Phyllis Phuah,Tanysha Chi-Ying Chen,Fidelia B. Alvina,Si Hui Tan,Kaushal Krishna Kaslikar,Nur Syahirah Ruhazat,Menaka Priyadharsani Rajapakse,Katzrin Bte Ahmad Murad,Snezhina Kancheva,Liang Thing Tan,Seri Mustafah,Jimmy Bok Yan So,Nick Barker
出处
期刊：Science
[American Association for the Advancement of Science]
日期：2025-12-18
卷期号：390 (6779): eadr2428-eadr2428
被引量：1
标识
DOI：10.1126/science.adr2428
摘要
CSCs in both initiating and sustaining cancer progression and demonstrated that AQP5 expression also directly promotes tumor growth and invasion in a WNT, PI3K (phosphatidylinositol 3-kinase), and MAPK (mitogen-activated protein kinase)-dependent manner. Beyond primary cancers, AQP5 further enriches for a functional CSC population in metastatic tumors. Together, our findings support a CSC model in gastric tumors that may have application for therapeutic strategies targeting CSCs.
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(2025-6-4)
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