Blood Pressure and Pulse Rate of Severe Preeclampsia s Receiving Magnesium Sulfate and Undergoing Cesarean Section under General Anesthesia

Background and Purpose. In women with severe preeclampsia, significantincreases in pulse rate and blood pressure are common after laryngoscopy and tracheal intubation of general anesthesia. There are various techniques by which this intubation-related stress response can be attenuated. Magnesium reduces the pressure response to intubation in women with pregnancy induced hypertension (PIH). Our purpose was to investigate ability magnesium to control pulse rate and blood pressure disturbances in preeclampsia patient.   Methods. We studied 18 patients with PIH, undergoing emergency cesarean section with general anesthesia. Measurement of systolic (SAP), diastolic and mean arterial pressure (MAP) and of heart rate were recorded in baseline, before induction until five minutes after induction of anesthesia and after extubation. We divide into two groups, patient has a sustained therapeutic level of magnesium (up to 6 hours) and less than 6 hours.   Result. Systolic arterial pressure increased after 5 minutes of tracheal intubation from 163 ± 25 mmHg to 168 ± 36 mmHg. MAP was from 120 ± 16 to 134 ± 22 mmHg, and heart rate increased from 103 ± 15 to 110 ± 13 beats per minute (bpm). The average in heart rate was 107 ± 10 bpm following extubation. In the study group, after administration of magnesium sulfate. There wasn’t a significant different (p > 0,005) in MAP, SAP and heart rate between therapeutic level group (≥ 6 hours) and < 6 hours, but more stable in therapeutic level group.   Conclusions. In this study, general anesthesia for cesarean delivery was associated with increased of SAP, MAP and heart rate following 5 minutes after intubation and extubation, but more stable in patient which administrated with magnesium sulfate in therapeutic level.