淋巴瘤
体内
癌症研究
细胞毒性
激酶
体外
生物
医学
免疫学
细胞生物学
遗传学
作者
Sophia Gayle,Sean F. Landrette,Neil Beeharry,Chris Conrad,Marylens Hernandez,Paul Beckett,Shawn M. Ferguson,Talya Mandelkern,Meiling Zheng,Tian Xu,Jonathan M. Rothberg,Henri S. Lichenstein
出处
期刊:Blood
[American Society of Hematology]
日期:2017-03-30
卷期号:129 (13): 1768-1778
被引量:141
标识
DOI:10.1182/blood-2016-09-736892
摘要
Key Points Apilimod has broad anticancer activity in vitro and in vivo across all subtypes of B-NHL. Apilimod induces B-NHL cytotoxicity through a unique mechanism of action that involves the disruption of lysosomal function.
科研通智能强力驱动
Strongly Powered by AbleSci AI