化学
生物利用度
药代动力学
药理学
生化工程
生物流体
全身循环
生物制药
生物药物
药物输送
生物活性
效力
医学
生物化学
色谱法
有机化学
体外
生药学
疾病
病理
工程类
内科学
作者
Alexander N. Zelikin,Carsten Ehrhardt,Anne Marie Healy
出处
期刊:Nature Chemistry
[Springer Nature]
日期:2016-10-21
卷期号:8 (11): 997-1007
被引量:249
摘要
Biological drugs generated via recombinant techniques are uniquely positioned due to their high potency and high selectivity of action. The major drawback of this class of therapeutics, however, is their poor stability upon oral administration and during subsequent circulation. As a result, biological drugs have very low bioavailability and short therapeutic half-lives. Fortunately, tools of chemistry and biotechnology have been developed into an elaborate arsenal, which can be applied to improve the pharmacokinetics of biological drugs. Depot-type release systems are available to achieve sustained release of drugs over time. Conjugation to synthetic or biological polymers affords long circulating formulations. Administration of biological drugs through non-parenteral routes shows excellent performance and the first products have reached the market. This Review presents the main accomplishments in this field and illustrates the materials and methods behind existing and upcoming successful formulations and delivery strategies for biological drugs.
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