Metformin vs. Pioglitazone as Initial Treatment for Diabetes

Metformin and the thiazolidinediones (e.g., pioglitazone [Actos] and rosiglitazone [Avandia]) are increasingly popular first-line drugs for type 2 diabetes. In this randomized, double-blind multicenter study from Europe, 1199 patients with type 2 diabetes and inadequate responses to diet alone received either metformin (titrated …