化学
代谢物
哌嗪
立体化学
吲哚试验
曲霉
烟曲霉
生物化学
有机化学
微生物学
生物
作者
Wei Xia,Jun-Cheng Su,Jinshan Hu,Xian-Hui He,Shuangjun Lin,Dongmei Zhang,Wen‐Cai Ye,Minfeng Chen,Hou‐Wen Lin,Cui‐Xian Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-12-13
卷期号:24 (1): 158-163
被引量:17
标识
DOI:10.1021/acs.orglett.1c03795
摘要
Comprehensive analyses of the metabolite spectra of Aspergillus sp. EGF 15-0-3 under different culture conditions revealed the presence of unique environmental-induced metabolites exclusively from the rice medium. Subsequent target isolation afforded four unprecedented indole diketopiperazine-based hybrids with a pyrano[3',2':7,8]isochromeno[4,3-b]pyrazino[2,1-i]indole core (1 and 2) or a spiro[piperazine-2,2'-pyrano[3,4,5-de]chromene] scaffold (3 and 4). Putative biosynthetic pathways for 1-4, with Diels-Alder cycloadditions as key steps, were proposed. 1-4 exhibited selective cytotoxicities among several human cancer cells.
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