Three New Polyketides from the Culture of Mangrove-Derived FungusEupenicilliumsp. HJ002

A pair of novel isochroman epimers eupenicilchromans A, B, and one new isocoumarin derivative eupenicilmarin A, together with five known compounds were isolated from the culture of mangrove-derived fungus Eupenicilium sp. HJ002. The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD) methods. Eupenicilchromans A, B showed potent antioxidant activeties with the IC50 values of 0.6 and 2.6 mmol/L, respectively, and eupenicilchroman A displayed better antioxidant activity than the positive control trolox (IC501.6 mmol/L).