SUMMARY A method is described for the isolation of eosinophils from the peritoneal cavity of the rat. Eosinophil granules were obtained from the isolated eosinophils. Lysis of eosinophil granules was found to be associated with the release from the granule of protein and peroxidase. The material released from eosinophil granules attached to foreign particles and the coated particles were readily ingested by mononuclear phagocytes.