蜂毒肽
纳米载体
化学
脂质体
肽
药物输送
单层
两亲性
生物物理学
脂质双层
纳米颗粒
纳米技术
膜
生物化学
有机化学
材料科学
共聚物
生物
聚合物
作者
Neelesh Soman,Gregory M. Lanza,John M. Heuser,Paul H. Schlesinger,Samuel A. Wickline
出处
期刊:Nano Letters
[American Chemical Society]
日期:2008-02-27
卷期号:8 (4): 1131-1136
被引量:124
摘要
The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of melittin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant ∼3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.
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