氧化应激
神经退行性变
脂质过氧化
DNA氧化
淀粉样蛋白(真菌学)
氧化磷酸化
阿尔茨海默病
生物化学
化学
DNA损伤
神经科学
衰老自由基理论
生物
细胞生物学
疾病
DNA
内科学
医学
氧化损伤
无机化学
作者
D. Allan Butterfield,Jennifer Drake,Chava B. Pocernich,Alessandra Castegna
标识
DOI:10.1016/s1471-4914(01)02173-6
摘要
Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD) patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is extensive in those AD brain areas in which Aβ is abundant. Recent research suggests that these observations might be linked, and it is postulated that Aβ-induced oxidative stress leads to neurodegeneration in AD brain. Consonant with this postulate, Aβ leads to neuronal lipid peroxidation, protein oxidation and DNA oxidation by means that are inhibited by free-radical antioxidants. Here, we summarize current research on phospholipid peroxidation, as well as protein and DNA oxidation, in AD brain, and discuss the potential role of Aβ in this oxidative stress.
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