细胞色素c
凋亡体
线粒体凋亡诱导通道
细胞凋亡
线粒体
细胞生物学
胞浆
化学
细胞色素b
程序性细胞死亡
生物
线粒体膜间隙
细胞色素C1
半胱氨酸蛋白酶
辅酶Q-细胞色素c还原酶
细胞色素
膜间隙
生物化学
细菌外膜
线粒体DNA
基因
酶
大肠杆菌
作者
Jie Yang,Xuesong Liu,Kapil N. Bhalla,Caryn Naekyung Kim,Ana Maria Ibrado,Jiyang Cai,Tao‐Chun Peng,Dean P. Jones,Xiaodong Wang
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1997-02-21
卷期号:275 (5303): 1129-1132
被引量:4683
标识
DOI:10.1126/science.275.5303.1129
摘要
Bcl-2 is an integral membrane protein located mainly on the outer membrane of mitochondria. Overexpression of Bcl-2 prevents cells from undergoing apoptosis in response to a variety of stimuli. Cytosolic cytochrome c is necessary for the initiation of the apoptotic program, suggesting a possible connection between Bcl-2 and cytochrome c, which is normally located in the mitochondrial intermembrane space. Cells undergoing apoptosis were found to have an elevation of cytochrome c in the cytosol and a corresponding decrease in the mitochondria. Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria.
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