苏拉明
细胞培养
体外
细胞生长
药理学
干扰素
活力测定
生长抑制
癌症研究
生物
化学
免疫学
生物化学
遗传学
作者
Alfredo Falcone,Romano Danesi,Lucia Zaccaro,D Pieracci,E. Pfanner,Claudia Cianci,M. Andreuccetti,Gino Malvaldi,M. Del Tacca,Pierfranco Conte
标识
DOI:10.1016/0959-8049(94)90429-4
摘要
Suramin, a polysulphonated naphthylurea proven to be an effective anticancer agent against selected tumours, and α2A-interferon (α2A-IFN) were investigated for their combined effects on HCT-8, HCT-15, CL-D, SW-480 and SW-620 human colorectal adenocarcinoma cell lines. All lines were sensitive to clinically achievable concentrations of suramin in a dose-dependent manner, while α2A-IFN alone induced only a modest reduction of cell growth. Concomitant treatment with suramin and α2A-IFN resulted in a synergistic inhibition of cell viability in each cell line at all doses tested. However, when suramin and α2A-IFN were administered sequentially, inhibition of cell viability was clearly dependent on the timing of treatment schedule, with maximum effect obtained when α2A-IFN was administered prior to suramin. In contrast, pretreatment with suramin was markedly inferior to the former one. In conclusion, suramin and α2A-IFN exert a synergistic effect on human colorectal cell proliferation in vitro at clinically achievable concentrations. This observation may have clinical relevance although the mechanisms of interaction remain to be elucidated.
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