基因组
核糖核酸
翻译(生物学)
生物
人类免疫缺陷病毒(HIV)
计算生物学
细胞生物学
遗传学
基因
病毒学
信使核糖核酸
作者
Sarah C. Keane,Xiao Heng,Kun Lu,Siarhei Kharytonchyk,Venkateswaran Ramakrishnan,Gregory Carter,Shawn Barton,Azra Hosic,Alyssa Florwick,Justin Santos,Nicholas C Bolden,Sayo McCowin,David A. Case,B. V. Johnson,Marco Salemi,Alice Telesnitsky,Michael F. Summers
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-05-22
卷期号:348 (6237): 917-921
被引量:212
标识
DOI:10.1126/science.aaa9266
摘要
Structural signals that direct HIV packaging During the viral replication cycle of HIV, unspliced dimeric RNA genomes are efficiently packaged into new virions at the host cell membrane. Packaging is directed by a region at the start of the genome, the 5′ leader. The architecture of the 5′ leader remains controversial. Keane et al. developed nuclear magnetic resonance methods to determine the structure of a 155-nucleotide-long region of the 5′ leader that can direct viral packaging. The structure shows how the 5′ leader binds to the HIV protein that directs packaging, how unspliced dimeric genomes are selected for packaging, and how translation is suppressed when the genome dimerizes. Science , this issue p. 917
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